PDZ and LIM domain protein 1(PDLIM1)/CLP36 promotes breast cancer cell migration, invasion and metastasis through interaction with α-actinin
Identifieur interne : 001C86 ( Main/Exploration ); précédent : 001C85; suivant : 001C87PDZ and LIM domain protein 1(PDLIM1)/CLP36 promotes breast cancer cell migration, invasion and metastasis through interaction with α-actinin
Auteurs : Zhongmin Liu [États-Unis] ; Yun Zhan [République populaire de Chine] ; Yizeng Tu [États-Unis] ; Ka Chen [États-Unis] ; Zhihua Liu [République populaire de Chine] ; Chuanyue Wu [États-Unis]Source :
- Oncogene [ 0950-9232 ] ; 2014.
Descripteurs français
- KwdFr :
- Actinine (métabolisme), Animaux, Facteurs de transcription (génétique), Facteurs de transcription (métabolisme), Femelle, Humains, Hétérogreffes, Invasion tumorale, Liaison aux protéines, Lignée cellulaire tumorale, Modèles animaux de maladie humaine, Mouvement cellulaire (génétique), Métastase tumorale, Prolifération cellulaire, Protéine G cdc42 (métabolisme), Protéines à domaine LIM (génétique), Protéines à domaine LIM (métabolisme), Souris, Tumeurs du sein (anatomopathologie), Tumeurs du sein (génétique), Tumeurs du sein (métabolisme).
- MESH :
- anatomopathologie : Tumeurs du sein.
- génétique : Facteurs de transcription, Mouvement cellulaire, Protéines à domaine LIM, Tumeurs du sein.
- métabolisme : Actinine, Facteurs de transcription, Protéine G cdc42, Protéines à domaine LIM, Tumeurs du sein.
- Animaux, Femelle, Humains, Hétérogreffes, Invasion tumorale, Liaison aux protéines, Lignée cellulaire tumorale, Modèles animaux de maladie humaine, Métastase tumorale, Prolifération cellulaire, Souris.
English descriptors
- KwdEn :
- Actinin (metabolism), Animals, Breast Neoplasms (genetics), Breast Neoplasms (metabolism), Breast Neoplasms (pathology), Cell Line, Tumor, Cell Movement (genetics), Cell Proliferation, Disease Models, Animal, Female, Heterografts, Humans, LIM Domain Proteins (genetics), LIM Domain Proteins (metabolism), Mice, Neoplasm Invasiveness, Neoplasm Metastasis, Protein Binding, Transcription Factors (genetics), Transcription Factors (metabolism), cdc42 GTP-Binding Protein (metabolism).
- MESH :
- chemical , genetics : LIM Domain Proteins, Transcription Factors.
- chemical , metabolism : Actinin, LIM Domain Proteins, Transcription Factors, cdc42 GTP-Binding Protein.
- genetics : Breast Neoplasms, Cell Movement.
- metabolism : Breast Neoplasms.
- pathology : Breast Neoplasms.
- Animals, Cell Line, Tumor, Cell Proliferation, Disease Models, Animal, Female, Heterografts, Humans, Mice, Neoplasm Invasiveness, Neoplasm Metastasis, Protein Binding.
Abstract
Increased CLP36 expression has been found to be closely associated with breast cancer progression. However, whether and how it contributes to malignant behavior of breast cancer cells were not known. We show here that CLP36 is critical for promoting breast cancer cell migration and invasion in vitro and metastasis in vivo, whereas it is dispensable for breast cell proliferation and anchorage independent growth in vitro and tumor growth in vivo. CLP36 interacted with both α-actinin-1 and -4 in breast cancer cells. Depletion of either α-actinin-1 or -4 inhibited breast cancer cell migration. Furthermore, mutations inhibiting the α-actinin-binding activity abolished the ability of CLP36 to promote breast cancer cell migration. Finally, depletion of CLP36 or disruption of the CLP36-α-actinin complex in breast cancer cells substantially inhibited Cdc42 activation, cell polarization and migration. Our results identify CLP36 as an important regulator of breast cancer cell migration and metastasis, and shed light on how increased CLP36 expression contributes to progression of breast cancer.
Url:
DOI: 10.1038/onc.2014.64
PubMed: 24662836
PubMed Central: 4175366
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="P1">Increased CLP36 expression has been found to be closely associated with breast cancer progression. However, whether and how it contributes to malignant behavior of breast cancer cells were not known. We show here that CLP36 is critical for promoting breast cancer cell migration and invasion in vitro and metastasis in vivo, whereas it is dispensable for breast cell proliferation and anchorage independent growth in vitro and tumor growth in vivo. CLP36 interacted with both α-actinin-1 and -4 in breast cancer cells. Depletion of either α-actinin-1 or -4 inhibited breast cancer cell migration. Furthermore, mutations inhibiting the α-actinin-binding activity abolished the ability of CLP36 to promote breast cancer cell migration. Finally, depletion of CLP36 or disruption of the CLP36-α-actinin complex in breast cancer cells substantially inhibited Cdc42 activation, cell polarization and migration. Our results identify CLP36 as an important regulator of breast cancer cell migration and metastasis, and shed light on how increased CLP36 expression contributes to progression of breast cancer.</p>
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<li>États-Unis</li>
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<region><li>Pennsylvanie</li>
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<settlement><li>Pékin</li>
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